Disulfiram Inclusion Complexes - A Nebulization Approach to Fight COVID-19

نویسندگان

چکیده

Disulfiram (DS) has an excellent anti-viral activity; however, its low water-solubility and first-pass metabolism are limiting clinical applications. Cyclodextrins (CDs) have been used as solubility enhancers carriers of DS proposed for inhalation to treat SARS-CoV-19. Two types CDs (hydroxypropyl β-cyclodextrin sulfobutyl ether β-cyclodextrin) were form inclusion complexes with DS, drug was assessed using spectrophotometric analytical method. Formulations freeze-dried characterized DSC, TGA FTIR. Nebulization technique assess the potential generating aerosols. All proved be suitable inhalation, therefore, potentially effective therapy further investigation against SARS-CoV-19 is shown. 

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ژورنال

عنوان ژورنال: British journal of pharmacy

سال: 2022

ISSN: ['2058-8356']

DOI: https://doi.org/10.5920/bjpharm.1149